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Protein transduction domain (PTD) or cell-penetrating peptide (CPP) can be used to deliver a wide range of molecular cargoes including peptides, proteins, nucleic acids, nanoparticles, and other therapeutic agents. One major limitation is their lack of tissue specificity or tropism, as they can facilitate cargo delivery across a broad range of cell types. In the present hypothesis, I propose a ligand-guided strategy to address this limitation and improve the cell specificity/

As a class of small peptide that facilitates cellular entry through energy-, receptor-, and endocytosis-independent manner, protein transduction domains (PTDs) have emerged as promising tools for nanosystem-based delivery of therapeutic agents, including proteins and small molecules. However, one of major challenges in using PTDs as drug delivery system is their lack of cell specificity or tropism. In my upcoming hypothesis, I will propose a strategy to address this limitatio

Potential role of mitochondria-eating protein (MIEAP) in regulating H1N1 pathogenesis and replication Clinical Relevance Globally, influenza A virus (IAV) infects approximately 1 billion people every year, resulting in more than 3 million cases of severe clinical manifestations and more than 290 thousand respiratory deaths. IAV is an enveloped, negative-sense, segmented single-stranded RNA virus with a wide range of hosts including humans, birds, swine, horses, and marine mam

Rapid replication of RNA viruses requires substantial cellular energy and effective mechanisms to evade cellular immunity. To meet these demands, many RNA viruses manipulate mitochondrial dynamics, including mitochondrial fragmentation and mitophagy. In the upcoming hypothesis, I propose a potential role for mitochondria-eating protein (MIEAP, also known as SPATA18), a novel regulator of non-canonical mitophagy, in the cellular pathogenesis and replication of H1N1 influenza v

Using computational approaches and a custom chemical structure database, I designed several novel indole derivatives that may target orthoflavivirus NS1 protein and alleviate NS1-associated pathology. Several unpublished in vitro and in vivo findings supporting this hypothesis are presented.

Using computational approaches, I have designed novel indole derivatives that may target the orthoflavivirus non-structural NS1 protein.

Pale splenic germinal centers in some nodules, suggesting an active immune response

Persistent Zika virus infection in immunocompetent mice can be established through intrasplenic viral inoculation