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Coinfections involving SARS-CoV-2 and orthoflaviviruses, including Zika virus, have been reported. However, the clinical characteristics and potential outcomes of Zika patients coinfected with SARS-CoV-2 remain unknown. In the upcoming hypothesis, I reanalyze proteomics profile of Zika virus (ZIKV)-infected cells and propose two potential players that may implicate to worsening COVID-19 prognosis.

As a class of small peptide that facilitates cellular entry through energy-, receptor-, and endocytosis-independent manner, protein transduction domains (PTDs) have emerged as promising tools for nanosystem-based delivery of therapeutic agents, including proteins and small molecules. However, one of major challenges in using PTDs as drug delivery system is their lack of cell specificity or tropism. In my upcoming hypothesis, I will propose a strategy to address this limitatio

Rapid replication of RNA viruses requires substantial cellular energy and effective mechanisms to evade cellular immunity. To meet these demands, many RNA viruses manipulate mitochondrial dynamics, including mitochondrial fragmentation and mitophagy. In the upcoming hypothesis, I propose a potential role for mitochondria-eating protein (MIEAP, also known as SPATA18), a novel regulator of non-canonical mitophagy, in the cellular pathogenesis and replication of H1N1 influenza v

Using computational approaches, I have designed novel indole derivatives that may target the orthoflavivirus non-structural NS1 protein.

Pale splenic germinal centers in some nodules, suggesting an active immune response