Protein transduction domain (PTD) or cell-penetrating peptide (CPP) can be used to deliver a wide range of molecular cargoes including peptides, proteins, nucleic acids, nanoparticles, and other therapeutic agents. One major limitation is their lack of tissue specificity or tropism, as they can facilitate cargo delivery across a broad range of cell types. In the present hypothesis, I propose a ligand-guided strategy to address this limitation and improve the cell specificity/

As a class of small peptide that facilitates cellular entry through energy-, receptor-, and endocytosis-independent manner, protein transduction domains (PTDs) have emerged as promising tools for nanosystem-based delivery of therapeutic agents, including proteins and small molecules. However, one of major challenges in using PTDs as drug delivery system is their lack of cell specificity or tropism. In my upcoming hypothesis, I will propose a strategy to address this limitatio