Potential role of mitochondria-eating protein (MIEAP) in regulating H1N1 pathogenesis and replication Clinical Relevance Globally, influenza A virus (IAV) infects approximately 1 billion people every year, resulting in more than 3 million cases of severe clinical manifestations and more than 290 thousand respiratory deaths. IAV is an enveloped, negative-sense, segmented single-stranded RNA virus with a wide range of hosts including humans, birds, swine, horses, and marine mam