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Using computational approaches and a custom chemical structure database, I designed several novel indole derivatives that may target orthoflavivirus NS1 protein and alleviate NS1-associated pathology. Several unpublished in vitro and in vivo findings supporting this hypothesis are presented.

Using computational approaches, I have designed novel indole derivatives that may target the orthoflavivirus non-structural NS1 protein.

Pale splenic germinal centers in some nodules, suggesting an active immune response

Persistent Zika virus infection in immunocompetent mice can be established through intrasplenic viral inoculation